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J. C. Eno Ltd., of Newcastle-upon-Tyne
1827 James Crossley Eno was born.
1850s These fast-acting effervescent fruit salts, which are used as an antacid and reliever of bloatedness, were invented by James Crossley Eno. 
1850s After serving as an apprentice to a pharmacy in Newcastle, then working at the Newcastle upon Tyne Infirmary, James Eno took over a pharmacy business in Newcastle, and then began to sell his remedies for constipation and sickness.
c1870s Eno's business was doing so well, he opened a factory at New Cross in London. The factory operated there for 40 years.
1938 Beechams Pills took over the company.
Eno was the most global of GlaxoSmithKline's gastrointestinal products.
2008 Many of the company's trademarks are still registered, including "Eno's Fruit Salts".