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of Blandfield Chemical Works, Wheatfield Road, Edinburgh, 11, Scotland. Telephone: Edinburgh 63922. Cables: "Meconic, Edinburgh". Also at 4 Carlos Place, London, W1. (1947)
1827 Company established as a chemists at 21-23 Duke Street, Edinburgh by brothers Thomas and Henry Smith.
1840 Having bought Blandfields Chemicals in Canongate and moved into their premises, the company developed the first liquid essence of coffee, later supplemented by creating various carbonated beverage flavours.
1848 Opened a branch in 12 Worship Street London.
1851 Company discovered Aloin.
1855 The first Morphine injection was developed. T and H Smith was the first company to produce commercial quantities of Apomorphine, and then Diamorphine in 1887.
1904 The company was registered on 9 February, to acquire the business of a company of practically similar title, manufacturing chemists and druggists. 
During World War I, the company supplied Morphine and over 7,500 long tons (7,600 t) of Lint-based medical dressings to the British Army.
1947 British Industries Fair Advert for Alkaloids, Fine Chemicals and Opium Derivatives. Manufacturers of Aloin, Chloroform, Dihydrohyoxocodeinone, Diacetyl-Morphine, Ethyl-morphine, Papaverine, Cantharidin, Dihydro-morphine, Gingerin, Phytostigmine, Capsicin, Dihydrocodeine, Homatorpine, Santonin, Chloral Hydrate, Dihydrocodeinone, Hyoscyamine, Scammony Resin. (Chemicals etc. Section - Olympia, Ground Floor, Stand No. A.1160)