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McDougall Brothers Ltd., of 66/68 Port Street, Manchester.
1845 Alexander McDougall, previously a struggling Scottish shoe merchant from Dumfries and then a Manchester schoolmaster, finally achieved his ambition of setting up as a manufacturing chemist.
He recruited his sons into the business.
1864 The McDougall Brothers (Alexander, Isaac, James Thomas, John and Arthur) developed and produced a patent substitute for yeast. This was the starting point which was not only to revolutionise home baking, but firmly position McDougall's as a household name, as pioneers of self-raising flour.
1867 Patent to Arthur McDougall, of the firm of McDougall Brothers, of the city of Manchester, Manufacturing Chemists, for the invention of "improvements in apparatus for stirring or agitating solid substances, and for exposing them to the action of the air, gases, and vapours."
1869 Milling became an important part of the business, especially after using different millers the results of their flour was varied, and at this time the company opened the Wheatsheaf Mill in the East End of London. The market for their self-raising flour had now extended into the South of England.
1869 The first large mill to be built alongside any of the London docks was the Wheatsheaf Mill, at Millwall Docks, which stood on the southern quay of the Millwall Outer Dock. Its construction was started in 1869 by the Manchester-based McDougall Brothers.
Also see McDougall Brothers for the part of the business concerned with flour.
1869 Patent to Aitken McDougall, of the firm of McDougall Brothers, of the city of Manchester, Manufacturing Chemists, for the invention of" improvements in the manufacture of blacking.
1873 Patent by John McDougall, of the firm of McDougall Brothers, of Manchester and London, Manufacturing Chemists, who has given notice in respect of the invention of "improvements in the manufacture of manures." 
1874 Patent by Isaac Shimwell McDougall, of the firm of McDougall Brothers, of Manchester andLondon, Manufacturing Chemists, in respect of the invention of " improvements in the furnaces used in the manufacture of alkali and other products."
1880 Dissolution of the Partnership between Alexander McDongall the younger, who retired from the business, with Isaac Shimwell McDougall, James Thomas McDougall, John McDougall, and Arthur McDougall, carrying on business in partnership under the firm of McDougall Brothers, as Manufacturing Chemists, at Port-street, in the city of Manchester, at the Irk Vale Chemical Works, Chadderton, in the county of Lancaster, at No. 10, Mark-lane, in the city of London, and at the Millwall Docks, London, and as Corn Millers, at the City Corn Mills, Poland-street, Manchester aforesaid, and at the Corn Mills, Millwall Docks aforesaid, and as Corn Merchants, at No. 99, Shudehill, Manchester aforesaid, and as Bakers, at No. 133, Strangeways, Manchester aforesaid. The said Isaac Shimwell McDougall, James Thomas McDougall, and John MoDougall, carried on business in partnership under firm of McDougall Brothers, as Manufacturing Chemists, at Port-street, Manchester aforesaid, at the Irk Yale Chemical Works aforesaid, at No. 10, Mark-lane aforesaid, and at the Millwall Docks aforesaid, and as Corn Millers, at the Mill-wall Docks aforesaid. The said Arthur McDougall will henceforth carry on business, under his own name, as a Corn Miller and Baker, at the City Corn Mills, Poland-street aforesaid, at No. 99, Shudehill aforesaid, and at No. 133, Strangeways aforesaid
1881 Alexander McDougall handed over the Manchester end of the business in order to devote more time to public life as an alderman and magistrate.
c. 1884 John McDougall, who had been running the London operation, did the same, eventually becoming Chairman of the London County Council and was knighted by Edward VII.
1900 Dissolution of the Partnership between Isaac Shimwell McDougall, James Thomas McDougall, and Isaac McDougall, carrying on business as Manufacturing Chemists, at Port street, Manchester, and Irk Vale Chemical Works, Chadderton, Lancashire, 10, Mark-lane, London, and Millwall Docks, London, under the style of McDougall Brothers. Isaac Shimwell McDougall and Isaac McDougall continued the business of Manufacturing Chemists, under the style of "McDougall Brothers."
1919 Weed Killer.
1926 The two companies were re-united as McDougalls Ltd